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How does ivosidenib drives cell differentiation?

03.09.2026
3

IVO Bridge – Episode 2
In this video, Dr. Eytan Stein presents how ivosidenib drives cell differentiation by inhibiting the mutant IDH1 enzyme to lower intracellular levels of 2-hydroxyglutarate, thereby removing the block in myeloid differentiation and allowing patients to go into remission.

Dr. Eytan Stein – Hematologist – Oncologist – Memorial Sloan Kettering Cancer Center, New York, USA

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